St. Louis, which came in near the bottom of the majors in home runs, jumped out to an early 4-0 lead with two long balls, including a three-run homer.
The Mets had several doubles providing scoring chances but went 2-11 with runners in scoring position, failing to capitalize on opportunities.
Noteworthy performances included Tomas Nido's double and homer, J.D. Martinez's two hits with a double in his Mets debut, and Brandon Nimmo's matching hits.
Harrison Bader and Brett Baty struggled at the bottom of the lineup, going a combined 0-6. Bader has been particularly cold, with just one hit in his last 18 at-bats.
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