Pellagra's devastation in the US highlights the importance of niacin. While its fortification has been a major public health advance, recent studies suggest a possible link to cardiovascular issues.
Studies have identified 2PY and 4PY, NAD-associated metabolites (not directly niacin-related), correlating with adverse cardiovascular events. Despite past benefits, these metabolites' new association with MACE raises concerns.
Previous research showcased niacin's mortality reduction and numerous positive effects. Recent focus on NAD-related metabolites and their potential ties to negative outcomes challenges the current understanding of niacin's impact on health.
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